The receiver operating characteristic (ROC) curve and its summary measure, the Area Under the Curve (AUC), are well-established tools for evaluating the efficacy of biomarkers in biomedical studies. Compared to the traditional ROC curve, the covariate-adjusted ROC curve allows for individual evaluation of the biomarker. However, the use of machine learning models has rarely been explored in this context, despite their potential to develop more powerful and sophisticated approaches for biomarker evaluation. The goal of this paper is to propose a framework for neural network-based covariate-adjusted ROC modeling that allows flexible and nonlinear evaluation of the effectiveness of a biomarker to discriminate between two reference populations. The finite-sample performance of our method is investigated through extensive simulation tests under varying dependency structures between biomarkers, covariates, and referenced populations. The methodology is further illustrated in a clinically case study that assesses daily physical activity - measured as total activity time (TAC), a proxy for daily step count-as a biomarker to predict mortality at three, five and eight years. Analyzes stratified by sex and adjusted for age and BMI reveal distinct covariate effects on mortality outcomes. These results underscore the importance of covariate-adjusted modeling in biomarker evaluation and highlight TAC's potential as a functional capacity biomarker based on specific individual characteristics.

The combination of Federated Learning (FL), Multimodal Large Language Models (MLLMs), and edge-cloud computing enables distributed and real-time data processing while preserving privacy across edge devices and cloud infrastructure. However, the deployment of MLLMs in FL environments with resource-constrained edge devices presents significant challenges, including resource management, communication overhead, and non-IID data. To address these challenges, we propose a novel hybrid framework wherein MLLMs are deployed on edge devices equipped with sufficient resources and battery life, while the majority of training occurs in the cloud. To identify suitable edge devices for deployment, we employ Particle Swarm Optimization (PSO), and Ant Colony Optimization (ACO) is utilized to optimize the transmission of model updates between edge and cloud nodes. This proposed swarm intelligence-based framework aims to enhance the efficiency of MLLM training by conducting extensive training in the cloud and fine-tuning at the edge, thereby reducing energy consumption and communication costs. Our experimental results show that the proposed method significantly improves system performance, achieving an accuracy of 92%, reducing communication cost by 30%, and enhancing client participation compared to traditional FL methods. These results make the proposed approach highly suitable for large-scale edge-cloud computing systems.

Abstract--This paper describes the development of a costeffective yet precise indoor robot navigation system composed of a custom robot controller board and an indoor positioning system. First, the proposed robot controller board has been specially designed for emerging IoT-based robot applications and is capable of driving two 6-Amp motor channels. Then, working together with the robot controller board, the proposed positioning system detects the robot's location using a down-looking webcam and uses the robot's position on the webcam images to estimate the real-world position of the robot in the environment. The positioning system can then send commands via WIFI to the robot in order to steer it to any arbitrary location in the environment. Our experiments show that the proposed system reaches a navigation error smaller or equal to 0.125 meters while being more than two orders of magnitude more cost-effective compared to off-the-shelve motion capture (MOCAP) positioning systems.

This survey paper explores the transformative role of Machine Learning (ML) and Artificial Intelligence (AI) in Cardiopulmonary Resuscitation (CPR). It examines the evolution from traditional CPR methods to innovative ML-driven approaches, highlighting the impact of predictive modeling, AI-enhanced devices, and real-time data analysis in improving resuscitation outcomes. The paper provides a comprehensive overview, classification, and critical analysis of current applications, challenges, and future directions in this emerging field.

Cardiopulmonary resuscitation (CPR) is a critical, life-saving intervention aimed at restoring blood circulation and breathing in individuals experiencing cardiac arrest or respiratory failure. Accurate and real-time analysis of biomedical signals during CPR is essential for monitoring and decision-making, from the pre-hospital stage to the intensive care unit (ICU). However, CPR signals are often corrupted by noise and artifacts, making precise interpretation challenging. Traditional denoising methods, such as filters, struggle to adapt to the varying and complex noise patterns present in CPR signals. Given the high-stakes nature of CPR, where rapid and accurate responses can determine survival, there is a pressing need for more robust and adaptive denoising techniques. In this context, an unsupervised machine learning (ML) methodology is particularly valuable, as it removes the dependence on labeled data, which can be scarce or impractical in emergency scenarios. This paper introduces a novel unsupervised ML approach for denoising CPR signals using a multi-modality framework, which leverages multiple signal sources to enhance the denoising process. The proposed approach not only improves noise reduction and signal fidelity but also preserves critical inter-signal correlations (0.9993) which is crucial for downstream tasks. Furthermore, it outperforms existing methods in an unsupervised context in terms of signal-to-noise ratio (SNR) and peak signal-to-noise ratio (PSNR), making it highly effective for real-time applications. The integration of multi-modality further enhances the system's adaptability to various biomedical signals beyond CPR, improving both automated CPR systems and clinical decision-making.

The proliferation of the Internet of Things (IoT) has led to an explosion of data generated by interconnected devices, presenting both opportunities and challenges for intelligent decision-making in complex environments. Traditional Reinforcement Learning (RL) approaches often struggle to fully harness this data due to their limited ability to process and interpret the intricate patterns and dependencies inherent in IoT applications. This paper introduces a novel framework that integrates transformer architectures with Proximal Policy Optimization (PPO) to address these challenges. By leveraging the self-attention mechanism of transformers, our approach enhances RL agents' capacity for understanding and acting within dynamic IoT environments, leading to improved decision-making processes. We demonstrate the effectiveness of our method across various IoT scenarios, from smart home automation to industrial control systems, showing marked improvements in decision-making efficiency and adaptability. Our contributions include a detailed exploration of the transformer's role in processing heterogeneous IoT data, a comprehensive evaluation of the framework's performance in diverse environments, and a benchmark against traditional RL methods. The results indicate significant advancements in enabling RL agents to navigate the complexities of IoT ecosystems, highlighting the potential of our approach to revolutionize intelligent automation and decision-making in the IoT landscape.

Recently, spam on online social networks has attracted attention in the research and business world. Twitter has become the preferred medium to spread spam content. Many research efforts attempted to encounter social networks spam. Twitter brought extra challenges represented by the feature space size, and imbalanced data distributions. Usually, the related research works focus on part of these main challenges or produce black-box models. In this paper, we propose a modified genetic algorithm for simultaneous dimensionality reduction and hyper parameter optimization over imbalanced datasets. The algorithm initialized an eXtreme Gradient Boosting classifier and reduced the features space of tweets dataset; to generate a spam prediction model. The model is validated using a 50 times repeated 10-fold stratified cross-validation, and analyzed using nonparametric statistical tests. The resulted prediction model attains on average 82.32\% and 92.67\% in terms of geometric mean and accuracy respectively, utilizing less than 10\% of the total feature space. The empirical results show that the modified genetic algorithm outperforms $Chi^2$ and $PCA$ feature selection methods. In addition, eXtreme Gradient Boosting outperforms many machine learning algorithms, including BERT-based deep learning model, in spam prediction. Furthermore, the proposed approach is applied to SMS spam modeling and compared to related works.

Currently, almost all direct marketing activities take place virtually rather than in person, weakening interpersonal skills at an alarming pace. Furthermore, businesses have been striving to sense and foster the tendency of their clients to accept a marketing offer. The digital transformation and the increased virtual presence forced firms to seek novel marketing research approaches. This research aims at leveraging the power of telemarketing data in modeling the willingness of clients to make a term deposit and finding the most significant characteristics of the clients. Real-world data from a Portuguese bank and national socio-economic metrics are used to model the telemarketing decision-making process. This research makes two key contributions. First, propose a novel genetic algorithm-based classifier to select the best discriminating features and tune classifier parameters simultaneously. Second, build an explainable prediction model. The best-generated classification models were intensively validated using 50 times repeated 10-fold stratified cross-validation and the selected features have been analyzed. The models significantly outperform the related works in terms of class of interest accuracy, they attained an average of 89.07\% and 0.059 in terms of geometric mean and type I error respectively. The model is expected to maximize the potential profit margin at the least possible cost and provide more insights to support marketing decision-making.

The Electronic Health Record (EHR) is an essential part of the modern medical system and impacts healthcare delivery, operations, and research. Unstructured text is attracting much attention despite structured information in the EHRs and has become an exciting research field. The success of the recent neural Natural Language Processing (NLP) method has led to a new direction for processing unstructured clinical notes. In this work, we create a python library for clinical texts, EHRKit. This library contains two main parts: MIMIC-III-specific functions and tasks specific functions. The first part introduces a list of interfaces for accessing MIMIC-III NOTEEVENTS data, including basic search, information retrieval, and information extraction. The second part integrates many third-party libraries for up to 12 off-shelf NLP tasks such as named entity recognition, summarization, machine translation, etc.

OceanX, a team of marine biologists, media and filmmakers, embarked on a quest in 2020 to explore the depths of the Red Sea where they not only found a giant shipwreck, but a massive creature that appeared to be larger than a human. While investigating the'Pella,' which sank in November 2011, at a depth of 2,800 feet, the group spotted what they thought could be'The Giant Squid.' 'I will never forget what happened next for as long as I live,' said OceanX science program lead Mattie Rodrigue in a video taken of the discovery. 'All of a sudden, as we're looking at the bow of the shipwreck, this massive creature comes into view, takes a look at the ROV [remotely operated vehicle] and curls its entire body around the bow of the wreck.' It was not until September 2021 did the team learn that the mysterious creature was'the giant form' of the purpleback flying squid, which typically grow up to two feet long. The OceanX team traveled to the Red Sea aboard the OceanXplorer, a research vessel with a 40-ton crane to launch submersibles, towed sonar arrays and other heavy equipment down into the depths.